TMEM50A

TMEM50A
Identifiers
Aliases	TMEM50A, IFNRC, SMP1, transmembrane protein 50A
External IDs	OMIM: 605348; MGI: 1919067; HomoloGene: 4469; GeneCards: TMEM50A; OMA:TMEM50A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	25,362,361 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,642,335 bp
RNA expression pattern
	Top expressed in
	monocyte; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; pericardium; ; parotid gland; ; gums; ; corpus epididymis; ; lactiferous duct; ; mucosa of sigmoid colon; ; gingival epithelium;
	Top expressed in
	adrenal gland; ; decidua; ; granulocyte; ; calvaria; ; thymus; ; stroma of bone marrow; ; umbilical cord; ; otolith organ; ; utricle; ; blood;
	More reference expression data
	More reference expression data
Orthologs
	23585
	71817
	ENSG00000183726
	ENSMUSG00000028822
	O95807
	Q9CXL1
	NM_014313
	NM_027935
	NP_055128
	NP_082211
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 50A is a protein that in humans is encoded by the TMEM50A gene.^[5]^[6]^[7]

This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183726 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028822 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Flegel WA, Wagner FF (Dec 2000). "Molecular genetics of RH". Vox Sang. 78 (Suppl 2): 109–15. PMID 10938938.
^ Wagner FF, Flegel WA (Aug 2000). "RHD gene deletion occurred in the Rhesus box". Blood. 95 (12): 3662–8. doi:10.1182/blood.V95.12.3662. PMID 10845894.
^ ^a ^b "Entrez Gene: TMEM50A transmembrane protein 50A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183726 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028822 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10938938-5] Flegel WA, Wagner FF (Dec 2000). "Molecular genetics of RH". Vox Sang. 78 (Suppl 2): 109–15. PMID 10938938.

[pmid10845894-6] Wagner FF, Flegel WA (Aug 2000). "RHD gene deletion occurred in the Rhesus box". Blood. 95 (12): 3662–8. doi:10.1182/blood.V95.12.3662. PMID 10845894.

[entrez-7] "Entrez Gene: TMEM50A transmembrane protein 50A".

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