TNF inhibitor

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response. TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their treatment. The important side effects of TNF inhibitors include lymphomas, infections (especially reactivation of latent tuberculosis), congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects.[1]

The global market for TNF inhibitors in 2008 was US$13.5 billion[2] and US$22 billion in 2009.[3]

  1. ^ Scheinfeld N (September 2004). "A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab". The Journal of Dermatological Treatment. 15 (5): 280–294. doi:10.1080/09546630410017275. PMID 15370396. S2CID 43332215.
  2. ^ Pappas DA, Bathon JM, Hanicq D, Yasothan U, Kirkpatrick P (September 2009). "Golimumab". Nature Reviews. Drug Discovery. 8 (9): 695–696. doi:10.1038/nrd2982. PMID 19721444.
  3. ^ "Top Ten/Twenty Best Selling Drugs 2009". Archived from the original on 2011-09-17. Retrieved 2011-09-08.