TNF receptor associated factor

"TRAF" redirects here. For the school, see Traf.

TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.[1]

Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.

Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.

  1. ^ Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T (January 2000). "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling". Exp. Cell Res. 254 (1): 14–24. doi:10.1006/excr.1999.4733. PMID 10623461.