TNIP2

TNIP2
Identifiers
Aliases	TNIP2, ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2
External IDs	OMIM: 610669; MGI: 2386643; HomoloGene: 11515; GeneCards: TNIP2; OMA:TNIP2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,741,648 bp[1] End 2,756,342 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,653,431 bp[2] End 34,671,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii pancreatic ductal cell granulocyte mucosa of transverse colon apex of heart gastric mucosa muscle layer of sigmoid colon body of stomach upper lobe of left lung monocyte Top expressed in neural layer of retina interventricular septum granulocyte lip right kidney primary visual cortex muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding metal ion binding polyubiquitin modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding Cellular component nucleus cytosol cytoplasm nucleoplasm Biological process negative regulation of endothelial cell apoptotic process regulation of transcription, DNA-templated CD40 signaling pathway protein stabilization positive regulation of macrophage activation transcription, DNA-templated stress-activated MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II apoptotic process toll-like receptor 9 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway protein deubiquitination cellular response to lipopolysaccharide interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79155 231130 Ensembl ENSG00000168884 ENSMUSG00000059866 UniProt Q8NFZ5 Q99JG7 RefSeq (mRNA) NM_024309 NM_001161527 NM_001292016 NM_139064 RefSeq (protein) NP_001154999 NP_001278945 NP_077285 NP_620703 Location (UCSC) Chr 4: 2.74 – 2.76 Mb Chr 5: 34.65 – 34.67 Mb PubMed search [3] [4]
Wikidata
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TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.^[5][6][7] TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.^[8]