TNS1

TNS1
Identifiers
Aliases	TNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDs	OMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 217,799,789 bp[1] End 218,002,995 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 38.17 cM Start 73,949,390 bp[2] End 74,163,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra tail of epididymis lower lobe of lung seminal vesicula myocardium of left ventricle cardiac muscle tissue of right atrium right coronary artery popliteal artery tibial arteries Top expressed in ascending aorta aortic valve interventricular septum right lung left lung right lung lobe left lung lobe muscle of thigh tunica media of zone of aorta myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding RNA binding Cellular component cytoplasm cell-substrate junction cell surface cell junction cytoskeleton focal adhesion Biological process cell-substrate junction assembly fibroblast migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7145 21961 Ensembl ENSG00000079308 ENSMUSG00000055322 UniProt Q9HBL0 Q0VG54 n/a RefSeq (mRNA) NM_001308022 NM_001308023 NM_022648 NM_001289895 NM_027884 NM_177169 RefSeq (protein) NP_001294951 NP_001294952 NP_072174 NP_001294951.1 NP_001294952.1 n/a Location (UCSC) Chr 2: 217.8 – 218 Mb Chr 1: 73.95 – 74.16 Mb PubMed search [3] [4]
Wikidata
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Tensin-1 is a protein that in humans is encoded by the TNS1 gene.^[5]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.^[5]