TNS1

TNS1
Identifiers
AliasesTNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDsOMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308022
NM_001308023
NM_022648

NM_001289895
NM_027884
NM_177169

RefSeq (protein)

NP_001294951
NP_001294952
NP_072174
NP_001294951.1
NP_001294952.1

n/a

Location (UCSC)Chr 2: 217.8 – 218 MbChr 1: 73.95 – 74.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[5]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079308Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055322Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNS1 tensin 1".