TPH2

TPH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V06
Identifiers
Aliases	TPH2, ADHD7, NTPH, tryptophan hydroxylase 2
External IDs	OMIM: 607478; MGI: 2651811; HomoloGene: 27831; GeneCards: TPH2; OMA:TPH2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	72,186,618 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	115,020,927 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; gonad; ; superior vestibular nucleus; ; islet of Langerhans; ; sural nerve; ; prefrontal cortex; ; anterior pituitary; ; white blood cell; ; monocyte;
	Top expressed in
	dorsal tegmental nucleus; ; central gray substance of midbrain; ; zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; enteric nervous system; ; sensory ganglion; ; trigeminal ganglion; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; tryptophan 5-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; oxidoreductase activity;
Cellular component	cytosol; neuron projection;
Biological process	cellular response to lithium ion; response to glucocorticoid; response to activity; serotonin biosynthetic process; response to estrogen; response to calcium ion; aromatic amino acid family metabolic process; response to nutrient levels; circadian rhythm; indolalkylamine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	121278
	216343
	ENSG00000139287
	ENSMUSG00000006764
	Q8IWU9
	Q8CGV2
	NM_173353
	NM_173391
	NP_775489
	NP_775567
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003,^[5] serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which tryptophan hydroxylase is the dominant form.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139287 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006764 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.
^ Zill P, Büttner A, Eisenmenger W, Möller HJ, Ackenheil M, Bondy B (2005). "Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study". Journal of Psychiatric Research. 41 (1–2): 168–173. doi:10.1016/j.jpsychires.2005.05.004. PMID 16023677.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139287 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006764 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.

[6] Zill P, Büttner A, Eisenmenger W, Möller HJ, Ackenheil M, Bondy B (2005). "Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study". Journal of Psychiatric Research. 41 (1–2): 168–173. doi:10.1016/j.jpsychires.2005.05.004. PMID 16023677.

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