TRADD

TRADD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F2H, 1F3V
Identifiers
Aliases	TRADD, Hs.89862, TNFRSF1A associated via death domain
External IDs	OMIM: 603500; MGI: 109200; HomoloGene: 2807; GeneCards: TRADD; OMA:TRADD - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,159,909 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,991,241 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; granulocyte; ; right uterine tube; ; mucosa of transverse colon; ; amniotic fluid; ; parotid gland; ; blood; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; gingival epithelium;
	Top expressed in
	intestinal villus; ; left colon; ; Ileal epithelium; ; lumbar spinal ganglion; ; jejunum; ; plantaris muscle; ; extensor digitorum longus muscle; ; duodenum; ; blood; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death domain binding; kinase binding; protein binding; identical protein binding; tumor necrosis factor receptor binding; protein-containing complex binding; molecular adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity;
Cellular component	cytoplasm; cytosol; receptor complex; plasma membrane; death-inducing signaling complex; membrane raft; cytoskeleton; nucleus; protein-containing complex;
Biological process	extrinsic apoptotic signaling pathway; positive regulation of hair follicle development; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; death-inducing signaling complex assembly; positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway via death domain receptors; I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein heterooligomerization; positive regulation of cell migration; positive regulation of inflammatory response; cellular response to tumor necrosis factor; positive regulation of NIK/NF-kappaB signaling; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8717
	71609
	ENSG00000102871
	ENSMUSG00000031887
	Q15628
	Q3U0V2
	NM_003789; NM_153425; NM_001323552
	NM_001033161
	NP_001310481; NP_003780
	NP_001028333
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.^[5]^[6]

TRADD is an adaptor protein.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102871 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031887 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu H, Xiong J, Goeddel DV (June 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell. 81 (4): 495–504. doi:10.1016/0092-8674(95)90070-5. PMID 7758105. S2CID 14301562.
^ "Entrez Gene: TRADD TNFRSF1A-associated via death domain".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102871 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031887 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7758105-5] Hsu H, Xiong J, Goeddel DV (June 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell. 81 (4): 495–504. doi:10.1016/0092-8674(95)90070-5. PMID 7758105. S2CID 14301562.

[entrez-6] "Entrez Gene: TRADD TNFRSF1A-associated via death domain".

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