TRAF4

TRAF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EOD, 2YUC, 3ZJB, 4K8U, 4M4E
Identifiers
Aliases	TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4
External IDs	OMIM: 602464; MGI: 1202880; HomoloGene: 3173; GeneCards: TRAF4; OMA:TRAF4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,750,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,056,415 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; right uterine tube; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; minor salivary glands; ; left lobe of thyroid gland; ; right lobe of liver; ; ganglionic eminence; ; gallbladder; ; rectum;
	Top expressed in
	yolk sac; ; right kidney; ; neural tube; ; ganglionic eminence; ; epiblast; ; ventricular zone; ; embryo; ; genital tubercle; ; embryo; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding; WW domain binding; thioesterase binding; tumor necrosis factor receptor binding; protein kinase binding; ubiquitin protein ligase binding; identical protein binding;
Cellular component	cytoplasm; membrane; bicellular tight junction; plasma membrane; cell junction; perinuclear region of cytoplasm; cytoskeleton; nucleus; protein-containing complex; intracellular anatomical structure;
Biological process	regulation of apoptotic process; activation of NF-kappaB-inducing kinase activity; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; respiratory gaseous exchange by respiratory system; multicellular organism development; respiratory tube development; signal transduction; positive regulation of protein kinase activity; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9618
	22032
	ENSG00000076604
	ENSMUSG00000017386
	Q9BUZ4
	Q61382
	NM_004295; NM_145751
	NM_009423
	NP_004286
	NP_033449
	Wikidata
View/Edit Human	View/Edit Mouse

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.^[5]^[6]^[7]

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins.^[8] TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017386 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem. 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751.
^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
^ "Entrez Gene: TRAF4 TNF receptor-associated factor 4".
^ Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
^ Kedinger V, Rio MC (2007). "TRAF4, the Unique Family Member". TNF Receptor Associated Factors (TRAFs). Advances in Experimental Medicine and Biology. Vol. 597. pp. 60–71. doi:10.1007/978-0-387-70630-6_5. ISBN 978-0-387-70629-0. PMID 17633017.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017386 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7592751-5] Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem. 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751.

[pmid7490069-6] Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.

[entrez-7] "Entrez Gene: TRAF4 TNF receptor-associated factor 4".

[pmid11384837-8] Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.

[pmid17633017-9] Kedinger V, Rio MC (2007). "TRAF4, the Unique Family Member". TNF Receptor Associated Factors (TRAFs). Advances in Experimental Medicine and Biology. Vol. 597. pp. 60–71. doi:10.1007/978-0-387-70630-6_5. ISBN 978-0-387-70629-0. PMID 17633017.

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