TRAF6

TRAF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M
Identifiers
Aliases	TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
External IDs	OMIM: 602355; MGI: 108072; HomoloGene: 3395; GeneCards: TRAF6; OMA:TRAF6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	36,510,272 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	101,532,014 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; gonad; ; islet of Langerhans; ; Achilles tendon; ; middle temporal gyrus; ; testicle; ; ascending aorta; ; monocyte; ; popliteal artery;
	Top expressed in
	Ileal epithelium; ; genital tubercle; ; tail of embryo; ; lumbar subsegment of spinal cord; ; lumbar spinal ganglion; ; granulocyte; ; thymus; ; ventricular zone; ; condyle; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; histone deacetylase binding; ubiquitin protein ligase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; zinc ion binding; protein binding; thioesterase binding; ubiquitin conjugating enzyme binding; protein kinase binding; protein kinase B binding; ubiquitin-protein transferase activity; identical protein binding; ubiquitin protein ligase binding; transferase activity; tumor necrosis factor receptor binding;
Cellular component	cytoplasm; cytosol; lipid droplet; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; nucleus; plasma membrane; cell cortex; endosome membrane; CD40 receptor complex; protein-containing complex;
Biological process	positive regulation of transcription regulatory region DNA binding; response to interleukin-1; toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; odontogenesis of dentin-containing tooth; animal organ morphogenesis; T-helper 1 type immune response; toll-like receptor 9 signaling pathway; regulation of apoptotic process; ossification; cytokine-mediated signaling pathway; osteoclast differentiation; positive regulation of osteoclast differentiation; stimulatory C-type lectin receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone resorption; JNK cascade; membrane protein intracellular domain proteolysis; protein ubiquitination; positive regulation of T cell proliferation; I-kappaB kinase/NF-kappaB signaling; protein autoubiquitination; immune system process; positive regulation of JUN kinase activity; positive regulation of DNA-binding transcription factor activity; protein polyubiquitination; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-2 production; positive regulation of T cell cytokine production; immune response; negative regulation of transcription, DNA-templated; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of protein ubiquitination; positive regulation of smooth muscle cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell development; protein K63-linked ubiquitination; myeloid dendritic cell differentiation; MyD88-dependent toll-like receptor signaling pathway; neural tube closure; bone remodeling; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; cellular response to lipopolysaccharide; T cell receptor signaling pathway; activation of protein kinase activity; positive regulation of transcription by RNA polymerase II; signal transduction; cellular response to DNA damage stimulus; protein deubiquitination; regulation of I-kappaB kinase/NF-kappaB signaling; interleukin-1-mediated signaling pathway; cellular response to cytokine stimulus; positive regulation of NIK/NF-kappaB signaling; positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
Orthologs
	7189
	22034
	ENSG00000175104
	ENSMUSG00000027164
	Q9Y4K3
	P70196
	NM_145803; NM_004620
	NM_009424; NM_001303273
	NP_004611; NP_665802
	NP_001290202; NP_033450
	Wikidata
View/Edit Human	View/Edit Mouse

TRAF6 is a TRAF human protein.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027164 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175104 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027164 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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