TRAIL

TNFSF10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90
Identifiers
Aliases	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A, tumor necrosis factor superfamily member 10, TNF superfamily member 10
External IDs	OMIM: 603598; MGI: 107414; HomoloGene: 2824; GeneCards: TNFSF10; OMA:TNFSF10 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.31 Start 172,505,508 bp[1] End 172,523,475 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 27,371,177 bp[2] End 27,396,576 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium urethra monocyte bronchial epithelial cell jejunal mucosa palpebral conjunctiva renal medulla rectum lower lobe of lung human penis Top expressed in conjunctival fornix mesenteric lymph nodes right kidney right lung lobe submandibular gland proximal tubule lumbar subsegment of spinal cord duodenum jejunum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity metal ion binding protein binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding signaling receptor binding zinc ion binding identical protein binding TRAIL binding Cellular component integral component of membrane membrane integral component of plasma membrane extracellular region extracellular exosome extracellular space plasma membrane Biological process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway cell-cell signaling cell surface receptor signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process immune response positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of apoptotic process male gonad development response to insulin regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8743 22035 Ensembl ENSG00000121858 ENSMUSG00000039304 UniProt P50591 P50592 RefSeq (mRNA) NM_001190942 NM_001190943 NM_003810 NM_009425 RefSeq (protein) NP_001177871 NP_001177872 NP_003801 NP_033451 Location (UCSC) Chr 3: 172.51 – 172.52 Mb Chr 3: 27.37 – 27.4 Mb PubMed search [3] [4]
Wikidata
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In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis.^[5][6]

TRAIL is a cytokine that is produced and secreted by most normal tissue cells. It causes apoptosis primarily in tumor cells,^[7] by binding to certain death receptors. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutics since the mid-1990s, such as Mapatumumab. However, as of 2013, these have not shown significant survival benefit.^[8] TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension.^[9]

TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).^[7]