TRIM5alpha

TRIM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ECV, 2YRG
Identifiers
Aliases	TRIM5, RNF88, TRIM5alpha, tripartite motif containing 5
External IDs	OMIM: 608487; MGI: 4821183; HomoloGene: 75345; GeneCards: TRIM5; OMA:TRIM5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,663,195 bp[1] End 5,938,619 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 103,987,961 bp[2] End 104,002,569 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve germinal epithelium palpebral conjunctiva stromal cell of endometrium body of pancreas seminal vesicula monocyte Descending thoracic aorta visceral pleura blood Top expressed in granulocyte thymus female urethra duodenum bone marrow aortic valve spleen ascending aorta esophagus mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein homodimerization activity pattern recognition receptor activity zinc ion binding metal ion binding protein binding identical protein binding protein kinase binding transferase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol omegasome intracellular anatomical structure nucleus P-body Biological process regulation of lipopolysaccharide-mediated signaling pathway interferon-gamma-mediated signaling pathway protein K63-linked ubiquitination immune system process protein trimerization positive regulation of DNA-binding transcription factor activity regulation of protein localization autophagy positive regulation of NF-kappaB transcription factor activity defense response to virus protein ubiquitination activation of innate immune response positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response viral process positive regulation of MAPK cascade pattern recognition receptor signaling pathway negative regulation of viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85363 319236 Ensembl ENSG00000132256 ENSMUSG00000057143 UniProt Q9C035 D3Z3L3 RefSeq (mRNA) NM_033034 NM_033092 NM_033093 NM_001146007 NM_175677 RefSeq (protein) NP_149023 NP_149083 NP_149084 NP_001139479 NP_783608 Location (UCSC) Chr 11: 5.66 – 5.94 Mb Chr 7: 103.99 – 104 Mb PubMed search [3] [4]
Wikidata
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Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene.^[5] The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates a species-specific early block to retrovirus infection.

TRIM5α is composed of 493 amino acids which is found in the cells of most primates. TRIM5α is an intrinsic immune factor important in the innate immune defense against retroviruses, along with the APOBEC family of proteins,^[6][7] tetherin and TRIM22.