TRIO (gene)

TRIO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NTY, 2NZ8
Identifiers
Aliases	TRIO, ARHGEF23, tgat, trio Rho guanine nucleotide exchange factor, MEBAS, MRD44, MRD63, TRIO gene
External IDs	OMIM: 601893; MGI: 1927230; HomoloGene: 20847; GeneCards: TRIO; OMA:TRIO - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	14,532,128 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	28,025,934 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; gastric mucosa; ; ganglionic eminence; ; right hemisphere of cerebellum; ; right ovary; ; left ovary; ; Achilles tendon; ; epithelium of colon; ; body of uterus;
	Top expressed in
	lateral septal nucleus; ; superior frontal gyrus; ; neural layer of retina; ; cerebellar cortex; ; internal carotid artery; ; human fetus; ; Rostral migratory stream; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; guanyl-nucleotide exchange factor activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; cytosol;
Biological process	phosphorylation; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; negative regulation of fat cell differentiation; G protein-coupled receptor signaling pathway; axon guidance; central nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	7204
	223435
	ENSG00000038382
	ENSMUSG00000022263
	O75962
	Q0KL02
	NM_007118
	NM_001081302
	NP_009049
	NP_001074771
	Wikidata
View/Edit Human	View/Edit Mouse

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000038382 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.
^ "Entrez Gene: TRIO triple functional domain (PTPRF interacting)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038382 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022263 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8643598-5] Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.

[entrez-6] "Entrez Gene: TRIO triple functional domain (PTPRF interacting)".

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