TRPM1

TRPM1
Identifiers
Aliases	TRPM1, CSNB1C, LTRPC1, MLSN1, transient receptor potential cation channel subfamily M member 1
External IDs	OMIM: 603576; MGI: 1330305; HomoloGene: 19940; GeneCards: TRPM1; OMA:TRPM1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	31,161,273 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	63,919,523 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; nipple; ; testicle; ; skin of leg; ; skin of abdomen; ; vulva; ; gonad; ; skin of thigh; ; human penis; ; C1 segment;
	Top expressed in
	iris; ; ciliary body; ; neural layer of retina; ; hair follicle; ; lens; ; retinal pigment epithelium; ; epithelium of lens; ; spermatocyte; ; stria vascularis; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel activity; ion channel activity; cation channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; new growing cell tip;
Biological process	G protein-coupled glutamate receptor signaling pathway; calcium ion transport into cytosol; response to stimulus; ion transport; protein tetramerization; calcium ion transmembrane transport; retinal rod cell development; cellular response to light stimulus; visual perception; signal transduction; ion transmembrane transport; transmembrane transport; cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	4308
	17364
	ENSG00000274965; ENSG00000134160
	ENSMUSG00000030523
	Q7Z4N2
	Q2TV84
	NM_001252020; NM_001252024; NM_001252030; NM_002420
	NM_001039104; NM_018752
	NP_001238949; NP_001238953; NP_001238959; NP_002411
	NP_001034193; NP_061222
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the TRPM1 gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000134160 GRCh38: Ensembl release 89: ENSG00000274965, ENSG00000134160 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030523 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, Shyjan AW (Nov 1998). "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)". Genomics. 54 (1): 116–23. doi:10.1006/geno.1998.5549. PMID 9806836.
^ Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (Apr 1998). "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis". Cancer Research. 58 (7): 1515–20. PMID 9537257.
^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] ENSG00000134160 GRCh38: Ensembl release 89: ENSG00000274965, ENSG00000134160 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030523 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806836-5] Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, Shyjan AW (Nov 1998). "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)". Genomics. 54 (1): 116–23. doi:10.1006/geno.1998.5549. PMID 9806836.

[pmid9537257-6] Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (Apr 1998). "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis". Cancer Research. 58 (7): 1515–20. PMID 9537257.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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