TRPM6

TRPM6
Identifiers
Aliases	TRPM6, CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6
External IDs	OMIM: 607009; MGI: 2675603; HomoloGene: 9767; GeneCards: TRPM6; OMA:TRPM6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	74,888,094 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	18,869,875 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; jejunal mucosa; ; rectum; ; mucosa of transverse colon; ; hair follicle; ; duodenum; ; testicle; ; gonad; ; gingival epithelium;
	Top expressed in
	conjunctival fornix; ; left colon; ; spermatid; ; right lung lobe; ; seminiferous tubule; ; zygote; ; right kidney; ; oocyte; ; secondary oocyte; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; ion channel activity; protein binding; cation channel activity; ATP binding; calcium channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; brush border membrane; apical plasma membrane;
Biological process	phosphorylation; metal ion transport; cation transport; ion transport; protein tetramerization; protein phosphorylation; calcium ion transmembrane transport; response to toxic substance; calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	140803
	225997
	ENSG00000119121
	ENSMUSG00000024727
	Q9BX84
	Q8CIR4
	NM_001177310; NM_001177311; NM_017662
	NM_153417
	NP_001170781; NP_001170782; NP_060132
	NP_700466
	Wikidata
View/Edit Human	View/Edit Mouse

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568. S2CID 40990544.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568. S2CID 40990544.

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