TRPM8

TRPM8
Identifiers
AliasesTRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
External IDsOMIM: 606678; MGI: 2181435; HomoloGene: 23433; GeneCards: TRPM8; OMA:TRPM8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024080

NM_134252

RefSeq (protein)

NP_076985

NP_599013

Location (UCSC)Chr 2: 233.92 – 234.02 MbChr 1: 88.21 – 88.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene.[5][6] The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans.[5][7] In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144481Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036251Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Andersen HH, Olsen RV, Møller HG, Eskelund PW, Gazerani P, Arendt-Nielsen L (March 2014). "A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia". European Journal of Pain. 18 (3): 315–25. doi:10.1002/j.1532-2149.2013.00380.x. PMID 23963768. S2CID 35385748.
  6. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
  7. ^ Cite error: The named reference pmid 24664788 was invoked but never defined (see the help page).
  8. ^ Werkheiser JL, Rawls SM, Cowan A (October 2006). "Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats". European Journal of Pharmacology. 547 (1–3): 101–5. doi:10.1016/j.ejphar.2006.07.026. PMID 16945367.