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Talgua Cave ("Cave of the Glowing Skulls"; “Cueva del Rio Talgua”) is a cave located in the Olancho Valley in the municipality of Catacamas in northeastern Honduras. The misnomer “The Cave of the Glowing Skulls” was given to the cave because of the way that light reflects off of the calcite deposits found on the skeletal remains found there. The site has gained the interest of archaeologists studying cave burials of Central America and of Mesoamerica as one of the most extensive Early to Middle Pre-Classic (~1000-900 BC in this case) ossuary cave sites currently known to have been in contact with the Maya societies of nearby Mesoamerica. It provides many valuable clues to how the inhabitants of the Talgua Cave may have been an important link between Pre-Columbian Mesoamerica and parts further south and east in Central America and extending into those societies in northern South America, a region known as the Isthmo-Colombian Area.