| Leptin | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the obese protein leptin-E100.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Leptin | ||||||||||
| Pfam | PF02024 | ||||||||||
| Pfam clan | CL0053 | ||||||||||
| InterPro | IPR000065 | ||||||||||
| SCOP2 | 1ax8 / SCOPe / SUPFAM | ||||||||||
| |||||||||||
Teleost leptins are a family of peptide hormones found in fish (teleostei) that are orthologs of the mammalian hormone leptin. The teleost and mammalian leptins appear to have similar functions, namely, regulation of energy intake and expenditure.
The leptin (LEP) hormone was long thought to be specific to mammals, but in recent years the gene (lep) has been found in amphibia such as the tiger salamander (Ambystoma tigrinum),[2][3] and the African clawed frog (Xenopus laevi).[4] The discovery of lep in puffer fish (Takifugu rubripes)[5] demonstrates the ancient ancestry of this hormone.
- ^ Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, et al. (May 1997). "Crystal structure of the obese protein leptin-E100". Nature. 387 (6629): 206–209. Bibcode:1997Natur.387..206Z. doi:10.1038/387206a0. PMID 9144295. S2CID 716518.
- ^ Al-Hussaniy HA, Alburghaif AH, Naji MA (2021). "Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions". Journal of Medicine and Life. 14 (5): 600–605. doi:10.25122/jml-2021-0153. PMC 8742898. PMID 35027962.
- ^ Boswell T, Dunn IC, Wilson PW, Joseph N, Burt DW, Sharp PJ (April 2006). "Identification of a non-mammalian leptin-like gene: characterization and expression in the tiger salamander (Ambystoma tigrinum)". General and Comparative Endocrinology. 146 (2): 157–166. doi:10.1016/j.ygcen.2005.08.001. hdl:20.500.11820/4d690bb6-fa7b-4d57-ae9d-98f3dfa1aebc. PMID 16480984.
- ^ Crespi EJ, Denver RJ (June 2006). "Leptin (ob gene) of the South African clawed frog Xenopus laevis". Proceedings of the National Academy of Sciences of the United States of America. 103 (26): 10092–10097. Bibcode:2006PNAS..10310092C. doi:10.1073/pnas.0507519103. PMC 1502511. PMID 16782821.
- ^ Cite error: The named reference
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