Telomerase RNA component

Ciliate telomerase RNA
Ciliate telomerase RNA
Identifiers
Symbol	Telomerase-cil
Rfam	RF00025
Other data
RNA type	Gene
Domain(s)	Eukaryote
PDB structures	PDBe

Vertebrate telomerase RNA
Vertebrate telomerase RNA
Identifiers
Symbol	Telomerase-vert
Rfam	RF00024
Other data
RNA type	Gene
Domain(s)	Eukaryote; Virus
PDB structures	PDBe

TERC
Identifiers
Aliases	TERC, DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR, Telomerase RNA component, TER
External IDs	OMIM: 602322; GeneCards: TERC; OMA:TERC - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	169,765,047 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; epithelium of colon; ; testicle; ; skeletal muscle tissue; ; sural nerve; ; Achilles tendon; ; tonsil; ; lung; ; kidney; ; blood;
	n/a
	More reference expression data
	n/a
Orthologs
	7012
	n/a
	ENSG00000277925
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Saccharomyces cerevisiae telomerase RNA

Identifiers
Symbol	Sacc_telomerase
Rfam	RF01050
Other data
RNA type	Gene
Domain(s)	Eukaryote
PDB structures	PDBe

Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres.^[3]^[4] TERC serves as a template for telomere replication (reverse transcription) by telomerase. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence. The vertebrate telomerase RNAs have a 3' H/ACA snoRNA-like domain.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000277925 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, et al. (September 1995). "The RNA component of human telomerase". Science. 269 (5228): 1236–41. Bibcode:1995Sci...269.1236F. doi:10.1126/science.7544491. PMID 7544491. S2CID 9440710.
^ Jády BE, Richard P, Bertrand E, Kiss T (February 2006). "Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres". Molecular Biology of the Cell. 17 (2): 944–54. doi:10.1091/mbc.E05-09-0904. PMC 1356602. PMID 16319170.
^ McCormick-Graham M, Romero DP (April 1995). "Ciliate telomerase RNA structural features". Nucleic Acids Research. 23 (7): 1091–7. doi:10.1093/nar/23.7.1091. PMC 306816. PMID 7739888.
^ Lingner J, Hendrick LL, Cech TR (August 1994). "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template". Genes & Development. 8 (16): 1984–98. doi:10.1101/gad.8.16.1984. PMID 7958872.
^ Theimer CA, Feigon J (June 2006). "Structure and function of telomerase RNA". Current Opinion in Structural Biology. 16 (3): 307–18. doi:10.1016/j.sbi.2006.05.005. PMID 16713250.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000277925 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7544491-3] Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, et al. (September 1995). "The RNA component of human telomerase". Science. 269 (5228): 1236–41. Bibcode:1995Sci...269.1236F. doi:10.1126/science.7544491. PMID 7544491. S2CID 9440710.

[pmid16319170-4] Jády BE, Richard P, Bertrand E, Kiss T (February 2006). "Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres". Molecular Biology of the Cell. 17 (2): 944–54. doi:10.1091/mbc.E05-09-0904. PMC 1356602. PMID 16319170.

[5] McCormick-Graham M, Romero DP (April 1995). "Ciliate telomerase RNA structural features". Nucleic Acids Research. 23 (7): 1091–7. doi:10.1093/nar/23.7.1091. PMC 306816. PMID 7739888.

[6] Lingner J, Hendrick LL, Cech TR (August 1994). "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template". Genes & Development. 8 (16): 1984–98. doi:10.1101/gad.8.16.1984. PMID 7958872.

[pmid16713250-7] Theimer CA, Feigon J (June 2006). "Structure and function of telomerase RNA". Current Opinion in Structural Biology. 16 (3): 307–18. doi:10.1016/j.sbi.2006.05.005. PMID 16713250.

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