Telomere-binding protein

Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat binding factor-1 (TERF1) and TTAGGG repeat binding factor-2 (TERF2).[1] Telomere sequences in humans are composed of TTAGGG sequences which provide protection and replication of chromosome ends to prevent degradation. Telomere-binding proteins can generate a T-loop to protect chromosome ends.[2] TRFs are double-stranded proteins which are known to induce bending, looping, and pairing of DNA which aids in the formation of T-loops. They directly bind to TTAGGG repeat sequence in the DNA.[3] There are also subtelomeric regions present for regulation. However, in humans, there are six subunits forming a complex known as shelterin.[4]

  1. ^ Database, GeneCards Human Gene. "TERF2 Gene - GeneCards | TERF2 Protein | TERF2 Antibody". www.genecards.org. Retrieved 2017-11-30.
  2. ^ Lee WK, Cho MH (June 2016). "Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana". Nucleic Acids Research. 44 (10): 4610–24. doi:10.1093/nar/gkw067. PMC 4889915. PMID 26857545.
  3. ^ Ilicheva NV, Podgornaya OI, Voronin AP (2015-01-01). Donev R (ed.). Advances in Protein Chemistry and Structural Biology. Vol. 101. Academic Press. pp. 67–96. doi:10.1016/bs.apcsb.2015.06.009. ISBN 9780128033678. PMID 26572976.
  4. ^ Sfeir A (September 2012). "Telomeres at a glance". Journal of Cell Science. 125 (Pt 18): 4173–8. doi:10.1242/jcs.106831. PMC 6518153. PMID 23135002.