Telomeric repeat-binding factor 1

TERF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BA5, 1ITY, 1IV6, 1W0T, 3BQO, 3L82, 5HKP
Identifiers
Aliases	TERF1, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1, telomeric repeat binding factor 1
External IDs	OMIM: 600951; MGI: 109634; HomoloGene: 7570; GeneCards: TERF1; OMA:TERF1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	73,048,123 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	15,914,276 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; spinal ganglia; ; tail of epididymis; ; pars reticulata; ; germinal epithelium; ; seminal vesicula; ; ventricular zone; ; trigeminal ganglion; ; pars compacta;
	Top expressed in
	yolk sac; ; tail of embryo; ; zygote; ; morula; ; epiblast; ; embryo; ; genital tubercle; ; blastocyst; ; maxillary prominence; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; double-stranded telomeric DNA binding; protein homodimerization activity; telomeric DNA binding; microtubule binding; telomerase activity; ubiquitin binding; protein binding; G-rich strand telomeric DNA binding; protein heterodimerization activity; DNA binding, bending; ankyrin repeat binding; protein C-terminus binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear telomere cap complex; spindle; nucleoplasm; chromosome; telomere; nucleolus; cytoskeleton; nucleus; fibrillar center; nuclear body; shelterin complex;
Biological process	telomere maintenance via telomerase; negative regulation of establishment of RNA localization to telomere; negative regulation of telomere maintenance via semi-conservative replication; meiotic telomere clustering; negative regulation of establishment of protein localization to telomere; negative regulation of telomerase activity; negative regulation of DNA replication; positive regulation of mitotic cell cycle; mitotic spindle assembly checkpoint signaling; cell division; positive regulation of shelterin complex assembly; G2/M transition of mitotic cell cycle; positive regulation of apoptotic process; positive regulation of microtubule polymerization; negative regulation of establishment of protein-containing complex localization to telomere; cell cycle; protein homooligomerization; positive regulation of mitotic nuclear division; telomeric loop formation; telomere capping; negative regulation of exonuclease activity; telomeric D-loop disassembly; t-circle formation; negative regulation of telomeric D-loop disassembly; negative regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomere lengthening; telomere maintenance; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7013
	21749
	ENSG00000147601
	ENSMUSG00000025925
	P54274
	P70371
	NM_003218; NM_017489
	NM_001286628; NM_009352
	NP_003209; NP_059523
	NP_001273557; NP_033378
	Wikidata
View/Edit Human	View/Edit Mouse

Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147601 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025925 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shen M, Haggblom C, Vogt M, Hunter T, Lu KP (January 1998). "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13618–23. doi:10.1073/pnas.94.25.13618. PMC 28355. PMID 9391075.
^ "Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147601 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025925 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9391075-5] Shen M, Haggblom C, Vogt M, Hunter T, Lu KP (January 1998). "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13618–23. doi:10.1073/pnas.94.25.13618. PMC 28355. PMID 9391075.

[entrez-6] "Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1".

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