Telomeric repeat-binding factor 2

TERF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H6P, 1VF9, 1VFC, 1W0U, 1XG1, 3BU8, 3BUA, 3K6G, 3SJM, 4M7C, 4RQI
Identifiers
Aliases	TERF2, TRBF2, TRF2, telomeric repeat binding factor 2
External IDs	OMIM: 602027; MGI: 1195972; HomoloGene: 4133; GeneCards: TERF2; OMA:TERF2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,355,567 bp[1] End 69,408,571 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.59 cM Start 107,069,400 bp[2] End 107,096,547 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 sural nerve ventricular zone ganglionic eminence postcentral gyrus epithelium of colon orbitofrontal cortex testicle prefrontal cortex gastrocnemius muscle Top expressed in tail of embryo genital tubercle internal carotid artery external carotid artery zygote Rostral migratory stream retinal pigment epithelium ciliary body secondary oocyte thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding double-stranded telomeric DNA binding protein homodimerization activity telomeric DNA binding telomerase activity protein C-terminus binding protein binding G-rich strand telomeric DNA binding enzyme binding protein-containing complex binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear telomere cap complex chromosome telomere Mre11 complex nucleus nucleoplasm nuclear body shelterin complex axon cytoplasm Biological process negative regulation of telomere single strand break repair regulation of telomere maintenance negative regulation of telomere maintenance via semi-conservative replication negative regulation of gene expression negative regulation of beta-galactosidase activity protein localization to chromosome, telomeric region cellular senescence negative regulation of telomere capping positive regulation of gene expression positive regulation of nitric-oxide synthase activity negative regulation of t-circle formation cell cycle telomeric loop formation negative regulation of cellular senescence telomere capping negative regulation of telomere maintenance via telomere lengthening negative regulation of exonuclease activity telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of telomere maintenance via recombination telomere maintenance RNA-dependent DNA biosynthetic process negative regulation of telomere maintenance regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via telomerase protection from non-homologous end joining at telomere regulation of transcription by RNA polymerase II anterograde axonal transport of messenger ribonucleoprotein complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7014 21750 Ensembl ENSG00000132604 ENSMUSG00000031921 UniProt Q15554 O35144 RefSeq (mRNA) NM_005652 NM_001083118 NM_001286200 NM_009353 RefSeq (protein) NP_005643 NP_001076587 NP_001273129 NP_033379 NP_001357994 NP_001357995 NP_001357996 Location (UCSC) Chr 16: 69.36 – 69.41 Mb Chr 8: 107.07 – 107.1 Mb PubMed search [3] [4]
Wikidata
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Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as TERF2, TRF2, and TRBF2, and is encoded in humans by the TERF2 gene.^[5] It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length, playing a key role in the protective activity of telomeres. It was first reported in 1997 in the lab of Titia de Lange,^[6] where a DNA sequence similar, but not identical, to TERF1 was discovered, with respect to the Myb-domain. De Lange isolated the new Myb-containing protein sequence and called it TERF2.