Tenascin C

TNC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEN, 2RB8, 2RBL
Identifiers
Aliases	TNC, 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, Tenascin C
External IDs	OMIM: 187380; MGI: 101922; HomoloGene: 55636; GeneCards: TNC; OMA:TNC - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.1 Start 115,019,575 bp[1] End 115,118,257 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C1|4 34.06 cM Start 63,878,022 bp[2] End 63,965,252 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tibial arteries cartilage tissue periodontal fiber tibia tendon of biceps brachii mucosa of paranasal sinus ventricular zone pericardium superficial temporal artery Top expressed in body of femur molar calvaria maxillary part of mouth facial skeleton upper jaw tibiofemoral joint second toe stroma of bone marrow belly cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syndecan binding extracellular matrix structural constituent protein binding Cellular component interstitial matrix membrane focal adhesion extracellular matrix basement membrane extracellular space endoplasmic reticulum lumen extracellular region collagen-containing extracellular matrix perisynaptic extracellular matrix Biological process cellular response to retinoic acid negative regulation of cell adhesion bud outgrowth involved in lung branching mesenchymal-epithelial cell signaling involved in prostate gland development response to fibroblast growth factor response to mechanical stimulus extracellular matrix organization wound healing cellular response to vitamin D odontogenesis of dentin-containing tooth positive regulation of gene expression cell adhesion prostate gland epithelium morphogenesis cellular response to prostaglandin D stimulus regulation of cell population proliferation neuromuscular junction development response to wounding peripheral nervous system axon regeneration osteoblast differentiation positive regulation of cell population proliferation response to ethanol neuron projection development post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3371 21923 Ensembl ENSG00000041982 ENSMUSG00000028364 UniProt P24821 Q80YX1 RefSeq (mRNA) NM_002160 NM_011607 NM_001369211 NM_001369212 NM_001369213 NM_001369214 RefSeq (protein) NP_002151 NP_035737 NP_001356140 NP_001356141 NP_001356142 NP_001356143 Location (UCSC) Chr 9: 115.02 – 115.12 Mb Chr 4: 63.88 – 63.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene.^[5][6] It is expressed in the extracellular matrix of various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system.^[7][8] Tenascin-C is the founding member of the tenascin protein family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage.