Tepoxalin

Tepoxalin
Skeletal formula of tepoxalin
Space-filling model of the tepoxalin molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATCvet code
Legal status
Legal status
Identifiers
  • 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.166.553 Edit this at Wikidata
Chemical and physical data
FormulaC20H20ClN3O3
Molar mass385.85 g·mol−1
3D model (JSmol)
  • CN(C(=O)CCc1cc(n(n1)c2ccc(cc2)OC)c3ccc(cc3)Cl)O
  • InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3 ☒N
  • Key:XYKWNRUXCOIMFZ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tepoxalin, sold under the brand name Zubrin[1] among others, is a non-steroidal anti-flammatory drug (NSAIDs) generally used in veterinary medicine to reduce swelling in animals with osteoarthritis.[1] In rare circumstances, tepoxalin can also be used in human pharmacology to relieve pain caused by musculoskeletal conditions such as arthritis and hip dysplasia.[2]

In 1997, tepoxalin was patented for veterinary use, replacing isoxazole for treating inflammation.[3] In 2017, the drug was withdrawn from the American market and can no longer be administered in the United States.[3]

Tepoxalin (C20H20ClN3O3) has been synthesized by several methods.[1] There are many perspectives on whether the consumption of tepoxalin on its own is more effective than combining it with antihistamines, but when applied in veterinary medicine, tepoxalin is regularly administered with antihistamines.[1]

  1. ^ a b c d Papich MG (2016). "Tepoxalin". Saunders Handbook of Veterinary Drugs Small and Large Animal (4th ed.). Elsevier. p. 762. ISBN 978-0-323-24485-5.
  2. ^ "epoxalin (Zubrin)". PetCoach. Petco Animal Supplies Stores, Inc.
  3. ^ a b Cite error: The named reference :0 was invoked but never defined (see the help page).