Tet methylcytosine dioxygenase 1

TET1
Identifiers
Aliases	TET1, CXXC6, LCX, bA119F7.1, MLL-TET1-MLL, Tet methylcytosine dioxygenase 1
External IDs	OMIM: 607790; MGI: 1098693; HomoloGene: 12735; GeneCards: TET1; OMA:TET1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,694,487 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,744,775 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; pancreatic ductal cell; ; tibialis anterior muscle; ; testicle; ; retinal pigment epithelium; ; deltoid muscle; ; sural nerve;
	Top expressed in
	trophoblast giant cell; ; Rostral migratory stream; ; tail of embryo; ; genital tubercle; ; blastocyst; ; ejaculatory duct; ; morula; ; primitive streak; ; embryo; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; zinc ion binding; methylcytosine dioxygenase activity; dioxygenase activity; metal ion binding; oxidoreductase activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of histone methylation; protein O-linked glycosylation; negative regulation of DNA methylation-dependent heterochromatin assembly; transcription, DNA-templated; stem cell population maintenance; inner cell mass cell differentiation; positive regulation of cell population proliferation; DNA demethylation; positive regulation of transcription by RNA polymerase II; chromatin organization; 5-methylcytosine catabolic process; oxidative demethylation;
	Sources:Amigo / QuickGO
Orthologs
	80312
	52463
	ENSG00000138336
	ENSMUSG00000047146
	Q8NFU7
	Q3URK3
	NM_030625
	NM_001253857; NM_027384
	NP_085128
	NP_001240786; NP_001393310; NP_001393311; NP_001393312
	Wikidata
View/Edit Human	View/Edit Mouse

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138336 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047146 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26.
^ Coulter JB, O'Driscoll CM, Bressler JP (October 2013). "Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase". The Journal of Biological Chemistry. 288 (40): 28792–28800. doi:10.1074/jbc.M113.491365. PMC 3789975. PMID 23940045.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047146 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26.

[Coulter_2013-6] Coulter JB, O'Driscoll CM, Bressler JP (October 2013). "Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase". The Journal of Biological Chemistry. 288 (40): 28792–28800. doi:10.1074/jbc.M113.491365. PMC 3789975. PMID 23940045.

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