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Pronunciation | /ˌtɛtrəˈsaɪkliːn/ |
Trade names | Tetracyn |
Other names | TE/TET/TC/TCY[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682098 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 80% |
Metabolism | Not metabolized |
Elimination half-life | 8–11 hours, 57–108 hours (kidney impairment) |
Excretion | Urine (>60%), feces |
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ECHA InfoCard | 100.000.438 |
Chemical and physical data | |
Formula | C22H24N2O8 |
Molar mass | 444.440 g·mol−1 |
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Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used to treat a number of infections,[3] including acne, cholera, brucellosis, plague, malaria, and syphilis.[3]
Common side effects include vomiting, diarrhea, rash, and loss of appetite.[3] Other side effects include poor tooth development if used by children less than eight years of age, kidney problems, and sunburning easily.[3] Use during pregnancy may harm the baby.[3] It works by inhibiting protein synthesis in bacteria.[3]
Tetracycline was patented in 1953[4] and was approved for prescription use in 1954.[5][6] It is on the World Health Organization's List of Essential Medicines.[7] Tetracycline is available as a generic medication.[3] Tetracycline was originally made from bacteria of the genus Streptomyces.[3]
History
was invoked but never defined (see the help page).