Tetryzoline

Tetryzoline
Clinical data
ATC code
Identifiers
  • (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.384 Edit this at Wikidata
Chemical and physical data
FormulaC13H16N2
Molar mass200.285 g·mol−1
3D model (JSmol)
Melting point117–119 °C (243–246 °F) [1] 256–257 °C (493–495 °F) for HCl-salt[2]
Solubility in waterVery soluble in water and ethanol, slightly soluble in chloroform and insoluble in diethylether[2] 
  • N\1=C(\NCC/1)C3c2ccccc2CCC3
  • InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15) checkY
  • Key:BYJAVTDNIXVSPW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tetryzoline (INN),[3] also known as tetrahydrozoline, is a drug used in some over-the-counter eye drops and nasal sprays. Tetryzoline was patented in 1954, and came into medical use in 1959.[4]

  1. ^ US 2731471, Synerholm M, Jules LH, Sahyun M, "Imidazoline Derivatives", issued 17 January 1956, assigned to Sahyun Laboratories. 
  2. ^ a b Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (2000). The Merck Index (12th ed.). Whitehouse Station, NJ, United States: Chapman & Hall Electronic Publishing Division. p. 1453. ISBN 978-1-58488-129-2. OCLC 46987702.
  3. ^ Cite error: The named reference WHOINN was invoked but never defined (see the help page).
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 552. ISBN 978-3-527-60749-5.