Theodore Styppeiotes or Stypeiotes (Greek: Θεόδωρος Στυπ[π]ειώτης, romanized: Theodōros Styp[p]eiōtēs) was a high-ranking bureaucrat of the Byzantine Empire and a member of the court of Emperor Manuel I Komnenos (r. 1143–1180). A well-educated and capable man, he advanced rapidly in the imperial hierarchy from imperial secretary (grammatikos) to the influential post of kanikleios, keeper of the imperial inkstand. In c. 1150 he engineered the downfall of John Hagiotheodorites, and succeeded him as mesazon, the de facto chief minister of the Empire. He long enjoyed the favour and trust of Manuel, who even wed him with his niece Eudokia. However, in 1158/59, Styppeiotes abruptly fell from power and was imprisoned and blinded. The sources provide different reasons, from Styppeiotes conspiring to deprive the Emperor of power to the machinations of his rival, John Kamateros, and scholars still dispute the true background of this event.