In the philosophy of science, observations are said to be "theory-laden" when they are affected by the theoretical presuppositions held by the investigator. The thesis of theory-ladenness is most strongly associated with the late 1950s and early 1960s work of Norwood Russell Hanson, Thomas Kuhn, and Paul Feyerabend, and was probably first put forth (at least implicitly) by Pierre Duhem about 50 years earlier.[1]
Semantic theory-ladenness refers to the impact of theoretical assumptions on the meaning of observational terms, while perceptual theory-ladenness refers to their impact on the perceptual experience itself. Theory-ladenness is also relevant for measurement outcomes: the data thus acquired may be said to be theory-laden since it is meaningless by itself unless interpreted as the outcome of the measurement processes involved.
Theory-ladenness poses a problem for the confirmation of scientific theories since the observational evidence may already implicitly presuppose the thesis it is supposed to justify. This effect can present a challenge for reaching scientific consensus if the disagreeing parties make different observations due to their different theoretical backgrounds.