| Thiamine pyridinylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.2 | ||||||||
| CAS no. | 9030-35-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
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| Aminopyrimidine aminohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.99.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thiaminase is an enzyme that metabolizes or breaks down thiamine into pyrimidine and thiazole. It is an antinutrient when consumed.
The old name was "aneurinase".[1]
There are two types with different Enzyme Commission numbers:[2]
- Thiamine pyridinylase, Thiaminase I (EC 2.5.1.2, InterPro: IPR030901)
- Aminopyrimidine aminohydrolase, Thinaminase II (EC 3.5.99.2, InterPro: IPR027574, IPR004305)
- 4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH2+[5]
- H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+[5]
- Produced by a wide range of plants and bacteria. In these organisms, it is mainly responsible for salvage of thiamine pyrimidine from degradation products, rather than the breakdown of thiamine.[5] In bacteria, it stays inside their cells.[6]
- ^ Fujita A, Nose Y, Kozuka S, Tashiro T, Ueda K, Sakamoto S (May 1952). "Studies on thiaminase. I. Activation of thiamine breakdown by organic bases". The Journal of Biological Chemistry. 196 (1): 289–95. doi:10.1016/S0021-9258(18)55732-X. PMID 12980969.
- ^ Thiaminases
- ^ "ENZYME - 2.5.1.2 thiamine pyridinylase". enzyme.expasy.org.
- ^ "UniProt P45741". www.uniprot.org.
- ^ a b c "ENZYME - 3.5.99.2 aminopyrimidine aminohydrolase". enzyme.expasy.org.
- ^ Cite error: The named reference
aneurinolyticuswas invoked but never defined (see the help page).