Thomas Asen Palaiologos (Latin: Thomas Assanus Paleologus, Greek: Θωμάς Ασάνης Παλαιολόγος; 15th century–1523?) was a prominent Byzantine exile in the Kingdom of Naples in the early 16th century. A descendant of two imperial dynasties, the Palaiologoi of Byzantium and the Asens of Bulgaria, Thomas Asen Palaiologos was active in the anti-Ottoman struggles of Greece. Before 1506, he resettled in Italy and was the donor for the construction of an Eastern Orthodox church in Naples.