Thomas Clayton (disambiguation)

Thomas Clayton (1777–1854) was an American lawyer and politician.

Thomas Clayton may also refer to:

• Thomas Clayton the Elder (1575-1647), physician and Regious Profess of Anatomy, Oxford
• Thomas Clayton (physician) (c. 1612–1693), MP for Oxford University
• Thomas Clayton (composer) (1673–1725), English musician and opera composer
• Thomas Clayton (American football) (born 1984), American football running back
• Tom Clayton (jockey) (1882–1909), Australian jockey
• Tom Clayton (footballer) (born 2000), English footballer
• Thomas J. Clayton (1826–1900), President Judge of the Thirty-Second Judicial District of Pennsylvania