Thomas Kilduff

Thomas Kilduff
Alma materUniversity of Florida
Stanford University
Known forDiscovery of hypocretin
Awards2009 AAAS Fellow
Scientific career
FieldsNeuroscience, particularly the neurobiology of sleep and wakefulness
InstitutionsAmes Research Center
Stanford University School of Medicine
SRI International
Academic advisorsWilse B. Webb, Craig Heller, Bill A. Williams, William C. Dement

Thomas S. Kilduff is an American neuroscientist and the director of SRI International's Center for Neuroscience. He specializes in neurobiology related to sleep and wakefulness, and was involved in the discovery of hypocretin (also known as orexin),[1][2] a neuropeptide system that is highly involved in wakefulness regulation.[3][4][5]

His group at SRI International also discovered an unusual neuronal population in the cerebral cortex that is activated during sleep.[6][7][8]

He is also a consulting professor at the Stanford University School of Medicine's Department of Psychiatry and Behavioral Sciences.[3]

  1. ^ de Lecea, L.; Kilduff, T.S.; Peyron, C.; Gao, X.-B.; Foye, P.E.; Danielson, P.E.; Fukuhara, C.; Battenberg, E.L.F.; Gautvik, V.T.; Bartlett II, F.S.; et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proceedings of the National Academy of Sciences USA. 95 (1, number 1): 322–327. Bibcode:1998PNAS...95..322D. doi:10.1073/pnas.95.1.322. PMC 18213. PMID 9419374.
  2. ^ Sakurai, T.; Amemiya, A.; Ishii, M.; Matsuzaki, I.; Chemelli, R.M.; Tanaka, H.; Williams, S.C.; Richardson, J.A.; Kozlowski, G.P.; Wilson, S.; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (4, number 4): 573–585. doi:10.1016/S0092-8674(00)80949-6. PMID 9491897. S2CID 16294729.
  3. ^ a b "Our People: Thomas Kilduff". SRI International. Retrieved 2013-04-28.
  4. ^ Thomas S. Kilduff; Ed S. Lein; Horacio de la Iglesia; Takeshi Sakurai; Ying-hui Fu & Paul Shaw (2008-11-12). "New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology". The Journal of Neuroscience. 28 (46): 11814–11818. doi:10.1523/jneurosci.3768-08.2008. PMC 2628168. PMID 19005045.
  5. ^ Kilduff, T.S. & Peyron, C. (2000). "The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders". Trends in Neurosciences. 23 (8, number 8): 359–365. doi:10.1016/s0166-2236(00)01594-0. PMID 10906799. S2CID 37955645.
  6. ^ "SRI International Research Team Identifies Rare Sleep-Activated Neurons in the Cerebral Cortex". SRI International. 2008-07-21. Retrieved 2013-06-15.
  7. ^ Gerashchenko, D.; Wisor, J.P.; Burns, D.; Reh, R.K.; Shiromani, P.J.; Sakurai, T.; de la Iglesia, H.O. & Kilduff, T.S (2008). "Identification of a population of sleep-active cerebral cortex neurons". Proceedings of the National Academy of Sciences USA. 105 (29): 10227–10232. Bibcode:2008PNAS..10510227G. doi:10.1073/pnas.0803125105. PMC 2481371. PMID 18645184.
  8. ^ Kilduff, T.S.; Cauli, B. & Gerashchenko, D. (2011). "Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?". Trends in Neurosciences. 34 (1, number 1): 10–19. doi:10.1016/j.tins.2010.09.005. PMC 3014438. PMID 21030095.