Thrombomodulin

THBD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTHBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
External IDsOMIM: 188040; MGI: 98736; HomoloGene: 308; GeneCards: THBD; OMA:THBD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000361

NM_009378

RefSeq (protein)

NP_000352

NP_033404

Location (UCSC)Chr 20: 23.05 – 23.05 MbChr 2: 148.25 – 148.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.[5] Thrombomodulin is also expressed on human mesothelial cell,[6] monocyte and a dendritic cell subset.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178726Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074743Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ IPR001491 Thrombomodulin Accessed January 19, 2012.
  6. ^ Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–549. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899. S2CID 8417511.