Thrombopoiesis is the formation of thrombocytes (blood platelets) in the bone marrow. Thrombopoietin is the main regulator of thrombopoiesis. Thrombopoietin affects most aspects of the production of platelets. This includes self-renewal and expansion of hematopoietic stem cells, stimulating the increase of megakaryocyte progenitor cells, and supporting these cells so they mature to become platelet-producing cells.[2] The process of Thrombopoiesis is caused by the breakdown of proplatelets (mature megakaryocyte membrane pseudopodial projections). During the process almost all of the membranes, organelles, granules, and soluble macromolecules in the cytoplasm are being consumed. Apoptosis also plays a role in the final stages of thrombopoiesis by letting proplatelet processes to occur from the cytoskeleton of actin.[3]
- ^ Betts JG, Young KA, Wise JA, Johnson E, Poe B, Kruse DH, Korol O, Johnson JE, Womble M, DeSaix P. "Ch. 1 Introduction - Anatomy and Physiology". OpenStax. Retrieved 2020-11-12.
{{cite book}}:|website=ignored (help) - ^ Kaushansky K (December 2005). "The molecular mechanisms that control thrombopoiesis". The Journal of Clinical Investigation. 115 (12): 3339–47. doi:10.1172/JCI26674. PMC 1297257. PMID 16322778.
- ^ Kaushansky K (February 2008). "Historical review: megakaryopoiesis and thrombopoiesis". Blood. 111 (3): 981–6. doi:10.1182/blood-2007-05-088500. PMC 2214745. PMID 18223171.