Thrombospondin

Thrombospondin type 1 domain
Thrombospondin-1
Identifiers
SymbolTSP_1
PfamPF00090
InterProIPR000884
SMARTSM00209
PROSITEPS50092
SCOP21lsl / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins.[1] The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.[2]

  1. ^ Morris, Aaron H.; Kyriakides, Themis R. (July 2014). "Matricellular proteins and biomaterials". Matrix Biology. 37: 183–191. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID 24657843.
  2. ^ Baenziger NL, Brodie GN, Majerus PW (January 1971). "A Thrombin-Sensitive Protein of Human Platelet Membranes". Proc. Natl. Acad. Sci. U.S.A. 68 (1): 240–3. Bibcode:1971PNAS...68..240B. doi:10.1073/pnas.68.1.240. PMC 391203. PMID 5276296.