Thrombospondin 1

THBS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE
Identifiers
Aliases	THBS1, THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
External IDs	OMIM: 188060; MGI: 98737; HomoloGene: 31142; GeneCards: THBS1; OMA:THBS1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q14 Start 39,581,079 bp[1] End 39,599,466 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.34 cM Start 117,942,357 bp[2] End 117,957,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastric mucosa pericardium gallbladder left uterine tube Achilles tendon right lung smooth muscle tissue upper lobe of left lung vena cava Top expressed in stroma of bone marrow calvaria body of femur retinal pigment epithelium granulocyte cumulus cell umbilical cord skin of external ear human fetus endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding extracellular matrix binding fibroblast growth factor binding phosphatidylserine binding proteoglycan binding collagen V binding fibrinogen binding low-density lipoprotein particle binding integrin binding laminin binding fibronectin binding identical protein binding transforming growth factor beta binding protein binding extracellular matrix structural constituent Cellular component endoplasmic reticulum lumen platelet alpha granule cell surface endoplasmic reticulum extracellular exosome extracellular matrix secretory granule platelet alpha granule lumen fibrinogen complex sarcoplasmic reticulum external side of plasma membrane cytoplasm extracellular space extracellular region collagen-containing extracellular matrix Biological process positive regulation of transforming growth factor beta receptor signaling pathway cellular response to heat negative regulation of fibrinolysis protein O-linked fucosylation response to progesterone response to magnesium ion positive regulation of translation negative regulation of endothelial cell migration negative regulation of cell-matrix adhesion negative regulation of long-chain fatty acid import across plasma membrane positive regulation of reactive oxygen species metabolic process positive regulation of blood coagulation positive regulation of blood vessel endothelial cell migration positive regulation of macrophage chemotaxis positive regulation of protein kinase B signaling negative regulation of plasminogen activation negative regulation of blood vessel endothelial cell migration negative regulation of extrinsic apoptotic signaling pathway response to endoplasmic reticulum stress positive regulation of endothelial cell apoptotic process response to unfolded protein positive regulation of chemotaxis negative regulation of cGMP-mediated signaling positive regulation of phosphorylation inflammatory response negative regulation of focal adhesion assembly chronic inflammatory response negative regulation of nitric oxide mediated signal transduction engulfment of apoptotic cell extracellular matrix organization positive regulation of macrophage activation sprouting angiogenesis negative regulation of apoptotic process response to glucose positive regulation of angiogenesis response to calcium ion positive regulation of transforming growth factor beta1 production cell adhesion behavioral response to pain immune response negative regulation of interleukin-12 production positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to hypoxia positive regulation of cell migration platelet degranulation negative regulation of endothelial cell chemotaxis negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration negative regulation of fibroblast growth factor receptor signaling pathway peptide cross-linking negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation negative regulation of angiogenesis cell migration positive regulation of fibroblast migration response to testosterone cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of transforming growth factor beta production response to mechanical stimulus positive regulation of cell population proliferation positive regulation of smooth muscle cell proliferation regulation of megakaryocyte differentiation negative regulation of cell migration involved in sprouting angiogenesis negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7057 21825 Ensembl ENSG00000137801 ENSMUSG00000040152 UniProt P07996 P35441 RefSeq (mRNA) NM_003246 NM_011580 NM_001313914 RefSeq (protein) NP_003237 n/a Location (UCSC) Chr 15: 39.58 – 39.6 Mb Chr 2: 117.94 – 117.96 Mb PubMed search [3] [4]
Wikidata
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Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.^[5][6]

Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.^[7][8]