Thromboxane receptor

TBXA2R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LBN
Identifiers
Aliases	TBXA2R, BDPLT13, TXA2-R, thromboxane A2 receptor
External IDs	OMIM: 188070; MGI: 98496; HomoloGene: 825; GeneCards: TBXA2R; OMA:TBXA2R - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,606,875 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,171,006 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; olfactory bulb; ; Descending thoracic aorta; ; buccal mucosa cell; ; popliteal artery; ; right coronary artery; ; tibial arteries; ; ascending aorta; ; Skeletal muscle tissue of rectus abdominis; ; vena cava;
	Top expressed in
	thymus; ; tunica media of zone of aorta; ; external carotid artery; ; internal carotid artery; ; sciatic nerve; ; belly cord; ; right kidney; ; carotid body; ; embryo; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; thromboxane receptor activity; guanyl-nucleotide exchange factor activity; signal transducer activity; thromboxane A2 receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; acrosomal vesicle; plasma membrane; nuclear speck;
Biological process	G protein-coupled receptor signaling pathway; response to nutrient; positive regulation of angiogenesis; signal transduction; cellular response to lipopolysaccharide; positive regulation of blood pressure; response to ethanol; thromboxane A2 signaling pathway; positive regulation of blood coagulation; positive regulation of vasoconstriction; response to testosterone; positive regulation of cytosolic calcium ion concentration; inflammatory response; regulation of vasoconstriction; second-messenger-mediated signaling; response to lipopolysaccharide; positive regulation of smooth muscle contraction; negative regulation of cell migration involved in sprouting angiogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6915
	21390
	ENSG00000006638
	ENSMUSG00000034881
	P21731
	P30987
	NM_001060; NM_201636
	NM_001277265; NM_009325; NM_001358512
	NP_001051; NP_963998
	NP_001264194; NP_033351; NP_001345441
	Wikidata
View/Edit Human	View/Edit Mouse

The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors^[5] and was the first eicosanoid receptor cloned.^[6] The TP receptor derives its name from its preferred endogenous ligand thromboxane A₂.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006638 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Devillier P, Bessard G (1997). "Thromboxane A₂ and related prostaglandins in airways". Fundam Clin Pharmacol. 11 (1): 2–18. doi:10.1111/j.1472-8206.1997.tb00163.x. PMID 9182072. S2CID 20514470.
^ Rolin S, Masereel B, Dogné JM (March 2006). "Prostanoids as pharmacological targets in COPD and asthma". Eur J Pharmacol. 533 (1–3): 89–100. doi:10.1016/j.ejphar.2005.12.058. PMID 16458293.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006638 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9182072-5] Devillier P, Bessard G (1997). "Thromboxane A₂ and related prostaglandins in airways". Fundam Clin Pharmacol. 11 (1): 2–18. doi:10.1111/j.1472-8206.1997.tb00163.x. PMID 9182072. S2CID 20514470.

[pmid16458293-6] Rolin S, Masereel B, Dogné JM (March 2006). "Prostanoids as pharmacological targets in COPD and asthma". Eur J Pharmacol. 533 (1–3): 89–100. doi:10.1016/j.ejphar.2005.12.058. PMID 16458293.

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