Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system.[5][6] It shares a common ancestor with IL-7.[7]
Originally appreciated for its role in immune cell proliferation and development, and then for its pivotal role in type 2 immune responses, TSLP is now known to be involved in other types of immune responses, autoimmune disease, and certain cancers.[5][6][8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145777 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024379 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Ebina-Shibuya R, Leonard WJ (January 2023). "Role of thymic stromal lymphopoietin in allergy and beyond". Nature Reviews. Immunology. 23 (1): 24–37. doi:10.1038/s41577-022-00735-y. PMC 9157039. PMID 35650271.
- ^ a b Tsilingiri K, Fornasa G, Rescigno M (March 2017). "Thymic Stromal Lymphopoietin: To Cut a Long Story Short". Cellular and Molecular Gastroenterology and Hepatology. 3 (2): 174–182. doi:10.1016/j.jcmgh.2017.01.005. PMC 5331833. PMID 28275684.
- ^ Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF (August 2016). "Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis". American Journal of Respiratory Cell and Molecular Biology. 55 (2): 264–274. doi:10.1165/rcmb.2015-0380OC. PMC 4979369. PMID 26934097.
- ^ Corren J, Ziegler SF (December 2019). "TSLP: from allergy to cancer". Nature Immunology. 20 (12): 1603–1609. doi:10.1038/s41590-019-0524-9. PMID 31745338. S2CID 208171881.