| thymidylate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Thymidylate synthase homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.1.45 | ||||||||
| CAS no. | 9031-61-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Thymidylate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Thymidylat_synt | ||||||||
| Pfam | PF00303 | ||||||||
| InterPro | IPR000398 | ||||||||
| PROSITE | PDOC00086 | ||||||||
| SCOP2 | 1tys / SCOPe / SUPFAM | ||||||||
| |||||||||
Thymidylate synthase (TS) (EC 2.1.1.45)[5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.[6][7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176890 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025747 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TYMS thymidylate synthetase".
- ^ "DNA: Form and Function" (PDF). Archived from the original (PDF) on 2013-05-25. Retrieved 2014-05-02.
- ^ "DNA Synthesis".