Thyrotropin-releasing hormone receptor

TRHR
Identifiers
Aliases	TRHR, TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs	OMIM: 188545; MGI: 98824; HomoloGene: 20707; GeneCards: TRHR; OMA:TRHR - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	109,121,565 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	44,099,308 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; gonad; ; pituitary gland; ; anterior pituitary; ; ventricle; ; atrium; ; right auricle; ; left ventricle; ; hippocampal formation;
	Top expressed in
	facial motor nucleus; ; lumbar subsegment of spinal cord; ; anterior amygdaloid area; ; anterior horn of spinal cord; ; motor neuron; ; ventral tegmental area; ; urethra; ; nucleus accumbens; ; dentate gyrus of hippocampal formation granule cell; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; thyrotropin-releasing hormone receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7201
	22045
	ENSG00000174417
	ENSMUSG00000038760
	P34981
	P21761
	NM_003301
	NM_013696
	NP_003292
	NP_038724
	Wikidata
View/Edit Human	View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.^[5]^[6]

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a G_αq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174417 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038760 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317. S2CID 44982871.
^ Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". Vol. 48. pp. 341–63. doi:10.1016/B978-0-12-571148-7.50016-6. ISBN 9780125711487. PMID 8382829. {{cite book}}: |journal= ignored (help); Missing or empty |title= (help)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174417 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038760 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8128317-5] Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317. S2CID 44982871.

[pmid8382829-6] Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". Vol. 48. pp. 341–63. doi:10.1016/B978-0-12-571148-7.50016-6. ISBN 9780125711487. PMID 8382829. {{cite book}}: |journal= ignored (help); Missing or empty |title= (help)

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