Tiapride

Not to be confused with Tianeptine or Tiagabine.
Tiapride
Clinical data
Trade namesTiapridal
Routes of
administration		Oral (tablets), IM, IV
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability~75% (oral) (Tmax = 1 hour)
Protein bindingNegligible
Elimination half-life2.9–3.6 hours
ExcretionUrine (70% as unchanged tiapride)
Identifiers
  • N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.051.717 Edit this at Wikidata
Chemical and physical data
FormulaC15H24N2O4S
Molar mass328.43 g·mol−1
3D model (JSmol)
  • CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC
  (verify)

Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.[2] A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Scatton B, Cohen C, Perrault G, Oblin A, Claustre Y, Schoemaker H, et al. (January 2001). "The preclinical pharmacologic profile of tiapride". European Psychiatry. 16 (Suppl 1): 29s–34s. doi:10.1016/s0924-9338(00)00526-5. PMID 11520476. S2CID 22686596.