Tight junction protein ZO-1

TJP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H2B, 2H2C, 2H3M, 2JWE, 2KXR, 2KXS, 2RCZ, 3CYY, 3LH5, 3SHU, 3SHW, 3TSV, 3TSW, 3TSZ, 4OEO, 4OEP, 4Q2Q, 4YYX
Identifiers
Aliases	TJP1, ZO-1, Tight junction protein 1
External IDs	OMIM: 601009; MGI: 98759; HomoloGene: 2445; GeneCards: TJP1; OMA:TJP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	29,968,915 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,177,529 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; sural nerve; ; placenta; ; tibial arteries; ; right lung; ; smooth muscle tissue; ; Achilles tendon; ; endometrium; ; epithelium of colon; ; C1 segment;
	Top expressed in
	left lung lobe; ; vestibular sensory epithelium; ; gastrula; ; vestibular membrane of cochlear duct; ; utricle; ; stria vascularis; ; external carotid artery; ; cumulus cell; ; epithelium of lens; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calmodulin binding; protein binding; cadherin binding; protein domain specific binding; connexin binding; protein C-terminus binding;
Cellular component	membrane; bicellular tight junction; plasma membrane; basolateral plasma membrane; gap junction; apical junction complex; cytosol; cytoplasm; apical part of cell; cell junction; podosome; cell projection; nucleus; cell-cell junction; adherens junction; intercalated disc; apical plasma membrane; apicolateral plasma membrane; intercellular canaliculus; tight junctions; protein-containing complex;
Biological process	establishment of endothelial intestinal barrier; hippo signaling; cell-cell junction assembly; regulation of bicellular tight junction assembly; blastocyst formation; hearing; response to lipopolysaccharide; negative regulation of vascular permeability; response to ethanol; response to magnetism; cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	7082
	21872
	ENSG00000277401; ENSG00000104067
	ENSMUSG00000030516
	Q07157
	P39447
NM_001301025; NM_001301026; NM_003257; NM_175610; NM_001330239;
	NM_001355012; NM_001355013; NM_001355014; NM_001355015
	NM_001163574; NM_009386
NP_001287954; NP_001287955; NP_001317168; NP_003248; NP_783297;
	NP_001341941; NP_001341942; NP_001341943; NP_001341944; NP_001287954.1; NP_001287955.1
	NP_001157046; NP_033412
	Wikidata
View/Edit Human	View/Edit Mouse

Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans.^[5] It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction-associated proteins and of which, ZO-1 is the first to be cloned. It was first isolated in 1986 by Stevenson and Goodenough using a monoclonal antibody raised in rodent liver to recognise a 225-kD polypeptide in whole liver homogenates and in tight junction-enriched membrane fractions.^[6] It has a role as a scaffold protein which cross-links and anchors Tight Junction (TJ) strand proteins, which are fibril-like structures within the lipid bilayer, to the actin cytoskeleton.^[7]

^ ^a ^b ^c ENSG00000104067 GRCh38: Ensembl release 89: ENSG00000277401, ENSG00000104067 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030516 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR (December 1995). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7". Genomics. 30 (3): 594–7. doi:10.1006/geno.1995.1281. PMID 8825647.
^ Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA (September 1986). "Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia". The Journal of Cell Biology. 103 (3): 755–66. doi:10.1083/jcb.103.3.755. PMC 2114282. PMID 3528172.
^ Itoh M, Nagafuchi A, Moroi S, Tsukita S (July 1997). "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments". The Journal of Cell Biology. 138 (1): 181–92. doi:10.1083/jcb.138.1.181. PMC 2139940. PMID 9214391.

[refGRCh38Ensembl-1] ENSG00000104067 GRCh38: Ensembl release 89: ENSG00000277401, ENSG00000104067 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030516 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8825647-5] Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR (December 1995). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7". Genomics. 30 (3): 594–7. doi:10.1006/geno.1995.1281. PMID 8825647.

[6] Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA (September 1986). "Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia". The Journal of Cell Biology. 103 (3): 755–66. doi:10.1083/jcb.103.3.755. PMC 2114282. PMID 3528172.

[7] Itoh M, Nagafuchi A, Moroi S, Tsukita S (July 1997). "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments". The Journal of Cell Biology. 138 (1): 181–92. doi:10.1083/jcb.138.1.181. PMC 2139940. PMID 9214391.

[1]

[2]

[3]

[4]

[5]

[6]

[7]