Toll-like receptor 10

TLR10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2J67
Identifiers
Aliases	TLR10, CD290, toll like receptor 10
External IDs	OMIM: 606270; HomoloGene: 12809; GeneCards: TLR10; OMA:TLR10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 38,772,238 bp[1] End 38,782,990 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node mucosa of ileum appendix spleen blood granulocyte monocyte epithelium of nasopharynx tonsil bone marrow cells n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane signaling receptor activity protein binding identical protein binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process toll-like receptor 10 signaling pathway inflammatory response positive regulation of inflammatory response MyD88-dependent toll-like receptor signaling pathway signal transduction immune system process innate immune response toll-like receptor signaling pathway immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81793 n/a Ensembl ENSG00000174123 n/a UniProt Q9BXR5 n/a RefSeq (mRNA) NM_001017388 NM_001195106 NM_001195107 NM_001195108 NM_030956 n/a RefSeq (protein) NP_001017388 NP_001182035 NP_001182036 NP_001182037 NP_112218 n/a Location (UCSC) Chr 4: 38.77 – 38.78 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.^[3] TLR10 has also been designated as CD290 (cluster of differentiation 290). TLR10 has not been extensively studied because it is a pseudogene in mice, though all other mammalian species contain an intact copy of the TLR10 gene. Unlike other TLRs, TLR10 does not activate the immune system and has instead been shown to suppress inflammatory signaling on primary human cells.^[4] This makes TLR10 unique among the TLR family. TLR10 was thought to be an "orphan" receptor, however, recent studies have identified ligands for TLR10 and these include HIV-gp41.^[5] Ligands for TLR2 are potential ligands for TLR10.^[6]