Toll-like receptor 6

TLR6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OM7
Identifiers
Aliases	TLR6, CD286, toll like receptor 6
External IDs	OMIM: 605403; MGI: 1341296; HomoloGene: 21223; GeneCards: TLR6; OMA:TLR6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 38,822,897 bp[1] End 38,856,817 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 33.54 cM Start 65,109,374 bp[2] End 65,117,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood lymph node granulocyte spleen appendix bone marrow cells Achilles tendon tonsil gallbladder Top expressed in granulocyte embryo blood stroma of bone marrow spleen muscle of thigh thymus calvaria carotid body tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Toll-like receptor 2 binding protein binding transmembrane signaling receptor activity lipopeptide binding amyloid-beta binding signaling receptor binding signaling receptor activity identical protein binding protein heterodimerization activity Cellular component integral component of membrane phagocytic vesicle membrane membrane integral component of plasma membrane cytoplasmic vesicle Golgi apparatus membrane raft Toll-like receptor 2-Toll-like receptor 6 protein complex plasma membrane intracellular anatomical structure receptor complex Biological process positive regulation of NLRP3 inflammasome complex assembly immune system process positive regulation of JUN kinase activity cellular response to diacyl bacterial lipopeptide activation of NF-kappaB-inducing kinase activity toll-like receptor 6 signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling inflammatory response toll-like receptor TLR6:TLR2 signaling pathway detection of diacyl bacterial lipopeptide signal transduction innate immune response T-helper 1 type immune response MyD88-dependent toll-like receptor signaling pathway nitric oxide metabolic process response to bacterial lipoprotein microglial cell activation toll-like receptor signaling pathway cell activation immune response positive regulation of gene expression negative regulation of toll-like receptor 2 signaling pathway TRIF-dependent toll-like receptor signaling pathway positive regulation of macrophage activation positive regulation of nitric oxide biosynthetic process positive regulation of NF-kappaB transcription factor activity cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of oxidative stress-induced neuron death positive regulation of reactive oxygen species biosynthetic process cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10333 21899 Ensembl ENSG00000174130 ENSMUSG00000051498 UniProt Q9Y2C9 Q9EPW9 RefSeq (mRNA) NM_006068 NM_001394553 NM_011604 NM_001359180 NM_001384171 RefSeq (protein) NP_006059 NP_035734 NP_001346109 NP_001371100 Location (UCSC) Chr 4: 38.82 – 38.86 Mb Chr 5: 65.11 – 65.12 Mb PubMed search [3] [4]
Wikidata
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Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.^[5] TLR6 is a transmembrane protein, member of toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. TLR6 acts in a heterodimer form with toll-like receptor 2 (TLR2). Its ligands include multiple diacyl lipopeptides derived from gram-positive bacteria and mycoplasma and several fungal cell wall saccharides. After dimerizing with TLR2, the NF-κB intracellular signalling pathway is activated, leading to a pro-inflammatory cytokine production and activation of innate immune response. TLR6 has also been designated as CD286 (cluster of differentiation 286).