Tolperisone

Tolperisone
Clinical data
Trade namesMydocalm and others
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, parenteral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
MetabolismLiver, kidney
Elimination half-life1st phase: 2 hrs
2nd phase: 12 hrs
ExcretionRenal
Identifiers
  • 2-methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.889 Edit this at Wikidata
Chemical and physical data
FormulaC16H23NO
Molar mass245.366 g·mol−1
3D model (JSmol)
  • C1CCCN(C1)CC(C(C2=CC=C(C=C2)C)=O)C
  • InChI=1S/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3 ☒N
  • Key:FSKFPVLPFLJRQB-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tolperisone (trade name Mydocalm among others) is a centrally acting skeletal muscle relaxant used for the treatment of increased muscle tone associated with neurological diseases. It has been used since the 1960s.[1][2]

  1. ^ "Tolperisone - referral | European Medicines Agency". www.ema.europa.eu. Retrieved 2024-03-04.
  2. ^ Quasthoff S, Möckel C, Zieglgänsberger W, Schreibmayer W (2008-05-14). "Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects". CNS Neuroscience & Therapeutics. 14 (2): 107–119. doi:10.1111/j.1527-3458.2008.00044.x. PMC 6494009. PMID 18482024.