Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Mouse |
Target | CD20 |
Clinical data | |
Trade names | Bexxar |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609013 |
ATC code | |
Identifiers | |
CAS Number | |
DrugBank | |
ChemSpider |
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UNII | |
KEGG | |
ChEMBL | |
Chemical and physical data | |
Formula | C6416H9874N1688O1987S44 |
Molar mass | 143860.04 g·mol−1 |
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Tositumomab is a murine monoclonal antibody which targets the CD20 antigen produced in mammalian cell.[1] It was combined with iodine-131 to produce a radiopharmaceutical for unsealed source radiotherapy, Iodine-131 Tositumomab (branded as Bexxar), for the treatment of non-Hodgkins lymphoma.[1] It is classified as a IgG2a lambda antibody.[1][2]
The drug combination was developed by Corixa which was purchased by GlaxoSmithKline in 2005.[3] It was sold for about $25,000 for one round of treatment.[4] Bexxar competed with Zevalin,[5] until the former's discontinuation in 2014.[6]