Toxic shock syndrome toxin-1

Toxic shock syndrome toxin-1
Crystallographic structure of TSST-1
Identifiers
Organism	Staphylococcus aureus
Symbol	tst
PDB	3TSS
RefSeq (Prot)	WP_001035596.1
UniProt	P06886
Search for Structures Swiss-model Domains InterPro

Toxic shock syndrome toxin-1 (TSST-1) is a superantigen with a size of 22 kDa^[1] produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumor necrosis factor. In general, the toxin is not produced by bacteria growing in the blood; rather, it is produced at the local site of an infection, and then enters the blood stream.