Transcription factor II B

GTF2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC
Identifiers
Aliases	GTF2B, TF2B, TFIIB, general transcription factor IIB
External IDs	OMIM: 189963; MGI: 2385191; HomoloGene: 1158; GeneCards: GTF2B; OMA:GTF2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.2 Start 88,852,633 bp[1] End 88,891,944 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H1 Start 142,470,806 bp[2] End 142,489,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon gingival epithelium epithelium of nasopharynx bone marrow islet of Langerhans olfactory zone of nasal mucosa mucosa of sigmoid colon palpebral conjunctiva Top expressed in primary oocyte zygote secondary oocyte spermatocyte spermatid medial ganglionic eminence primitive streak Paneth cell jejunum facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription factor binding protein binding metal ion binding thyroid hormone receptor binding TBP-class protein binding RNA polymerase II complex binding acetyltransferase activity promoter-specific chromatin binding RNA polymerase II core promoter sequence-specific DNA binding zinc ion binding histone acetyltransferase activity transferase activity acyltransferase activity RNA polymerase II complex recruiting activity RNA polymerase II general transcription initiation factor activity Cellular component nucleus nucleoplasm transcription factor TFIID complex nuclear body transcription preinitiation complex chromosome protein-DNA complex RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of viral transcription snRNA transcription by RNA polymerase II viral process transcription preinitiation complex assembly positive regulation of core promoter binding transcription initiation from RNA polymerase II promoter protein acetylation positive regulation by host of viral transcription positive regulation of transcription initiation from RNA polymerase II promoter transcriptional start site selection at RNA polymerase II promoter transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly RNA polymerase II core complex assembly histone acetylation DNA-templated transcription, initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2959 229906 Ensembl ENSG00000137947 ENSMUSG00000028271 UniProt Q00403 P62915 RefSeq (mRNA) NM_001514 NM_145546 RefSeq (protein) NP_001505 NP_663521 Location (UCSC) Chr 1: 88.85 – 88.89 Mb Chr 3: 142.47 – 142.49 Mb PubMed search [3] [4]
Wikidata
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Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)^[5] and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded by the TFIIB gene,^[6][7] and is homologous to archaeal transcription factor B and analogous to bacterial sigma factors.^[8]