Transcription factor Jun

JUN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Identifiers
Aliases	JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
External IDs	OMIM: 165160; MGI: 96646; HomoloGene: 1679; GeneCards: JUN; OMA:JUN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.1 Start 58,776,845 bp[1] End 58,784,048 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C5|4 43.34 cM Start 94,937,271 bp[2] End 94,940,459 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava gastric mucosa cardia lactiferous duct saphenous vein seminal vesicula pericardium parotid gland endothelial cell pylorus Top expressed in granulocyte left lung lobe dermis right lung decidua medial head of gastrocnemius muscle right lung lobe ventricular zone temporal muscle aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cAMP response element binding R-SMAD binding HMG box domain binding transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding enzyme binding chromatin binding protein binding double-stranded DNA binding DNA binding sequence-specific DNA binding transcription coactivator activity identical protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding RNA binding protein homodimerization activity protein heterodimerization activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding transcription cis-regulatory region binding Cellular component cytosol transcription repressor complex nucleus nuclear chromosome nucleoplasm transcription regulator complex transcription factor AP-1 complex Biological process negative regulation of neuron apoptotic process negative regulation of DNA binding outflow tract morphogenesis transcription by RNA polymerase II learning monocyte differentiation response to organic substance leading edge cell differentiation Fc-epsilon receptor signaling pathway positive regulation of neuron apoptotic process cellular response to hormone stimulus regulation of DNA-binding transcription factor activity circadian rhythm angiogenesis positive regulation of ERK1 and ERK2 cascade Ras protein signal transduction transforming growth factor beta receptor signaling pathway negative regulation of cell population proliferation response to muscle stretch cellular response to calcium ion response to cytokine regulation of transcription, DNA-templated SMAD protein signal transduction axon regeneration positive regulation of fibroblast proliferation response to mechanical stimulus positive regulation of epithelial cell migration positive regulation of DNA-templated transcription, initiation transcription, DNA-templated positive regulation of cell differentiation positive regulation of monocyte differentiation positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of protein autophosphorylation membrane depolarization negative regulation of apoptotic process eyelid development in camera-type eye microglial cell activation positive regulation of DNA replication response to lipopolysaccharide response to radiation response to cAMP negative regulation of transcription, DNA-templated response to hydrogen peroxide positive regulation of smooth muscle cell proliferation positive regulation of endothelial cell proliferation response to organic cyclic compound ageing regulation of cell cycle regulation of cell population proliferation positive regulation of cell population proliferation liver development negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress cellular response to potassium ion starvation cellular process release of cytochrome c from mitochondria positive regulation of transcription by RNA polymerase II positive regulation of GTPase activity cellular response to reactive oxygen species positive regulation of apoptotic process positive regulation of transcription, DNA-templated cellular response to cadmium ion negative regulation of transcription by RNA polymerase II positive regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3725 16476 Ensembl ENSG00000177606 ENSMUSG00000052684 UniProt P05412 P05627 RefSeq (mRNA) NM_002228 NM_010591 RefSeq (protein) NP_002219 NP_034721 Location (UCSC) Chr 1: 58.78 – 58.78 Mb Chr 4: 94.94 – 94.94 Mb PubMed search [3] [4]
Wikidata
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Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered.^[5] The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun (P05411).^[6] The viral homolog v-jun was discovered in avian sarcoma virus 17 and was named for ju-nana, the Japanese word for 17.^[7] The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.^[8]